Steven Watt and Paul Lawson will be missing for County as they travel to face their Highland rivals.
Defender Watt and midfielder Lawson are both injured and will play no part as County continue a demanding sequence of league and cup fixtures.
Inverness manager Terry Butcher: "I have to pick a side that keeps everyone fresh for the run-in but I have to balance that against winning this game and keeping our promotion hopes going.
"Everyone at Inverness is desperate to go back up so I will need to think long and hard about my starting line-up.
"This should be some game as our local rivals will be out to knock us off top spot but we are determined to keep ourselves up there."
Ross County manager Derek Adams: "This is the latest game in a demanding schedule and I would be delighted if we came through unbeaten in all four encounters.
"We had the better chances when we met up at our place but never scored and the game ended goalless.
"We have won in Inverness already this season plus another win would see us match last season's points total."
Source: BBC Sport
Source: BBC Sport